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Related Experiment Video

Updated: Jul 9, 2026

External Cephalic Version: Is it an Effective and Safe Procedure?

External Cephalic Version: Is it an Effective and Safe Procedure?

Published on: June 6, 2020

INDUCTION OF LABOUR WITH MISOPROSTOL - A PROSTAGLANDIN E1 ANALOGUE.

S Kumar¹, R T Awasthi², A Kapur³

¹Classified Specialist (Obstetrics & Gynaecology), INHS Asvini, Colaba, Mumbai 400 005.

Medical Journal, Armed Forces India

|July 14, 2016

Summary

Intravaginal misoprostol offers a faster labor induction compared to dinoprostone/oxytocin. While uterine tachysystole was more frequent, safety and delivery outcomes remained comparable for labor induction.

Keywords:

Induction of labour Misoprostol

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Published on: July 7, 2023

Area of Science:

Obstetrics and Gynecology
Reproductive Medicine

Background:

Cervical ripening and labor induction are critical in managing various pregnancy complications.
Existing protocols often involve dinoprostone and oxytocin, with varying efficacy and safety profiles.

Purpose of the Study:

To compare the safety and efficacy of intravaginal misoprostol with the standard hospital protocol (intracervical dinoprostone and oxytocin) for cervical ripening and labor induction.

Main Methods:

A randomized controlled trial involving 200 patients requiring labor induction.
Patients were assigned to receive either intravaginal misoprostol (25 mcg every 6 hours) or intracervical dinoprostone followed by oxytocin.
Outcomes measured included time to delivery, mode of delivery, and maternal/fetal complications.

Main Results:

The interval from induction to vaginal delivery was significantly shorter with misoprostol (1315±811 min) versus dinoprostone/oxytocin (1512±712 min) (p < 0.01).
No significant difference was observed in the route of delivery, with Cesarean section rates at 18% for misoprostol and 23% for dinoprostone/oxytocin.
Uterine tachysystole occurred more frequently with misoprostol (p < 0.01), but without an increased incidence of uterine hyperstimulation.

Conclusions:

Intravaginal misoprostol is a viable alternative for labor induction, demonstrating a shorter induction-to-delivery interval compared to the dinoprostone/oxytocin protocol.
Despite a higher rate of uterine tachysystole, misoprostol did not increase adverse perinatal outcomes, suggesting a favorable safety profile.
Further research may explore optimizing misoprostol dosage and monitoring to mitigate tachysystole risks.