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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
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Study of Drug Resistant Pulmonary Tuberculosis
R B Deoskar1, B Sengupta2, K E Rajan3
1Classified Specialist (Medicine and Respiratory Medicine), Military Hospital, Cardio Thoracic Centre, Pune-40.
Medical Journal, Armed Forces India
|July 14, 2016
Summary
Drug resistance in pulmonary tuberculosis (PT) is a significant challenge. This study found that while drug resistance occurs, most patients achieve sputum conversion with reserve drugs, indicating a manageable outcome.
Area of Science:
- Pulmonology
- Infectious Diseases
- Microbiology
Background:
- Drug resistance in pulmonary tuberculosis (PT) presents a growing management problem.
- The incidence of drug-resistant PT necessitates understanding resistance patterns and treatment responses.
Purpose of the Study:
- To determine the incidence and patterns of drug resistance in pulmonary tuberculosis.
- To evaluate the treatment response in patients with drug-resistant PT.
Main Methods:
- Sixty patients with drug-resistant PT were identified from 835 clinically diagnosed cases treated between January 2000 and May 2002.
- Analysis included incidence, drug resistance patterns, and treatment outcomes, including sputum conversion rates.
Main Results:
- Drug resistance was found in 7.2% of PT cases, with 14.8% of Mycobacterium tuberculosis strains resistant to at least one antitubercular drug.
- Initial resistance was noted in 66.7% of cases, while 33.3% developed acquired resistance. Resistance to multiple drugs was common.
- Sputum conversion was achieved in 98.3% of patients after initiating reserve drugs, with an average conversion time of 10 weeks.
Conclusions:
- The incidence of drug resistance in this study was lower than reported elsewhere.
- The majority of drug-resistant PT cases demonstrated satisfactory treatment outcomes with reserve medications.
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