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Hepato-biliary Scintigraphy in diagnosis of Biliary Atresia
S S Anand1, R K Handa2, Jogender Singh3
1Sr Adv (Nuclear Medicine), AH (R&R), New Delhi.
Background:
Biliary Atresia and Neonatal Hepatitis are the two major causes of Persistent Neonatal Jaundice. Differentiation is done by biochemical and radiological tests. Radiological investigations use intra-or extra-hepatic biliary dilation for diagnosing biliary atresia but this is not always reliable.
Methods:
14 neonates with persistent conjugated hyperbilirubinemia who had undergone hepato-biliary scintigraphy were retrospectively evaluated and those having Extrahepatic Biliary Atresia were analyzed with reference to operative findings.
Results:
11 out of 14 had Extrahepatic Biliary Atresia during operation whereas 3 proved to be false positive.
Conclusion:
Mebrofenin hepato - biliary scintigraphy is a simple, safe, accurate and cost effective investigation for diagnosis of biliary atresia.
