Related Experiment Video
Updated: Mar 18, 2026

10:52
Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
6.7K
Percutaneous Closure of Perimembranous Ventricular Septal Defect with Amplatzer Device
P Bharadwaj1, A Banerji1, R Datta1
1Senior Advisor (Medicine & Cardiology), MH (CTC), Pune.
Medical Journal, Armed Forces India
|July 14, 2016
Summary
The Amplatzer device offers a safe and effective percutaneous closure for perimembranous ventricular septal defects (PMVSD). Short-term results show high success rates and complete shunt occlusion, though long-term follow-up is needed.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Perimembranous ventricular septal defects (PMVSD) are often treated surgically.
- Percutaneous closure offers a less invasive alternative for PMVSD.
- The Amplatzer perimembranous ventricular septal occluder is a key device in this field.
Purpose of the Study:
- To evaluate the safety and efficacy of the Amplatzer device for percutaneous PMVSD closure.
- To assess short-term outcomes and complications associated with the procedure.
Main Methods:
- A cohort of 14 patients with PMVSD underwent percutaneous closure using the Amplatzer device.
- Patient demographics included a mean age of 10.53 years and mean weight of 20.64 kg.
- Device implantation success and shunt occlusion were monitored.
Main Results:
- Successful implantation was achieved in 92% of cases.
- Complete shunt occlusion was observed in all patients within three months post-procedure.
- No device-related aortic or tricuspid insufficiency or left ventricular dysfunction was noted.
Conclusions:
- The Amplatzer device demonstrates excellent short-term efficacy and safety for PMVSD closure.
- Potential complications include device embolization and complete heart block requiring pacemaker implantation.
- Long-term follow-up is essential to confirm sustained outcomes.

