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Growth in Children with Steroid Sensitive Nephrotic Syndrome
1Graded Specialist (Pediatrics), MH Allahabad, UP:-211001.
Steroid treatment for childhood nephrotic syndrome can cause growth retardation. Higher cumulative steroid doses in children with steroid-sensitive nephrotic syndrome correlate with more significant growth impairment.
Area of Science:
- Pediatric Nephrology
- Endocrinology
- Growth and Development
Background:
- Nephrotic syndrome is common in children aged 2-8 years.
- Steroids are the primary treatment for nephrotic syndrome.
- Relapsing cases raise concerns about growth impacts.
Purpose of the Study:
- To investigate the relationship between cumulative steroid dose and growth in children with steroid-sensitive nephrotic syndrome (SSNS).
Main Methods:
- Retrospective analysis of 35 children with SSNS.
- Divided into two groups: steroids only, and steroids with other medications.
- Measured height and calculated SD scores over one year, correlating growth rate with cumulative steroid dose.
Main Results:
- A negative correlation was observed between cumulative steroid dose and growth rate (Pearson's r = -0.341).
- This "fair correlation" indicates that increased steroid dosage is associated with greater growth retardation.
- Group I (steroids only) showed a stronger correlation (r = -0.441) than Group II.
Conclusions:
- Growth retardation is directly proportional to the cumulative steroid dose in children with SSNS.
- This highlights the need for careful steroid management to balance efficacy and growth.
- Further research may explore strategies to mitigate steroid-induced growth issues.
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