Renal Transplantation: Experience at a Single Centre.

Area of Science:

• Nephrology
• Transplantation Immunology
• Surgical Outcomes

Background:

• The Armed Forces renal transplantation program began in February 1991.
• Over 245 renal transplants have been performed at INHS Asvini.
• Protocols for donor/recipient evaluation and immunosuppression are described.

Purpose of the Study:

• To evaluate the outcomes of renal transplantation in the Armed Forces.
• To describe the protocols for donor and recipient evaluation.
• To detail immunosuppression strategies and patient rehabilitation.

Main Methods:

• 245 renal transplants were analyzed, with 99.2% from live donors.
• Triple immunosuppression (cyclosporine, azathioprine, prednisolone) was standard.
• Newer agents (mycophenolate, tacrolimus, sirolimus) were used selectively.

Main Results:

• 28.1% experienced acute rejection, mostly steroid-responsive.
• Graft and patient survival rates at 1 and 5 years were 97.2%/93% and 80.9%/85.7%, respectively.
• Complications included infections, post-transplant diabetes mellitus, and acute tubular necrosis.

Conclusions:

• Renal transplantation is a viable renal replacement therapy for end-stage kidney disease.
• The program demonstrates successful patient rehabilitation.
• Outcomes support transplantation as a beneficial treatment option.