Related Experiment Video

Updated: Mar 18, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K

Impact of Body Mass Index on Left Ventricular Function

D S Chadha1, A Swamy1, S K Malani2

  • 1Classified Specialist (Cardiology), Command Hospital (AF), Bangalore.

Medical Journal, Armed Forces India
|July 14, 2016
PubMed

Insights

Obesity is linked to heart problems. This study found subclinical diastolic dysfunction in obese individuals, which worsens with higher body mass index (BMI).

Area of Science:

  • Cardiology
  • Obesity Research
  • Echocardiography

Background:

  • Obesity is a significant risk factor for cardiovascular disease.
  • The direct impact of obesity on cardiac function requires further elucidation.
  • This study investigates the relationship between isolated obesity and left ventricular function.

Purpose of the Study:

  • To determine the direct effect of varying grades of obesity on echocardiographic indices.
  • To assess systolic and diastolic left ventricular function in obese individuals.
  • To correlate body mass index (BMI) with cardiac function parameters.

Main Methods:

  • Echocardiographic assessment of systolic and diastolic function in 51 obese and 25 normal-weight individuals.
  • Classification into normal weight (BMI <25kg/m²), overweight (BMI 25-29.9 kg/m²), and obese (BMI >30 kg/m²) groups.
  • Dysfunction defined as ≥ 2 SD deviation from normal weight group values.

Main Results:

  • Increased ejection fraction and fractional shortening in overweight and obese groups.
  • Enlarged left ventricular dimensions without changes in relative wall thickness.
  • Prevalence of subclinical diastolic dysfunction in obese subjects, correlating with BMI.
  • No systolic dysfunction observed; diastolic dysfunction noted in all obesity grades.

Conclusions:

  • Subclinical left ventricular diastolic dysfunction is present across all obesity grades.
  • Diastolic dysfunction in obesity is directly correlated with body mass index (BMI).
  • Obesity, even without other comorbidities, impacts diastolic cardiac function.
Abstract

Keywords:
Diastolic functionEchocardiographyObesitySystolic function

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.8K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

20.3K

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.1K
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
863
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
627
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.5K