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Acquired Platelet Dysfunction with Eosinophilia (APDE) Syndrome: A Case Report
Diksha D Yadav1, Priyanka S Nayar1, Rumma V Manchanda1
1Department of Pathology, KEM Hospital, 489, Sardar Moodliar Road, Rasta Peth, Pune, 411011 Maharashtra India.
Summary
Acquired platelet dysfunction with eosinophilia (APDE) is a rare bleeding disorder causing temporary platelet dysfunction alongside high eosinophil counts. This case highlights APDE in an 11-year-old boy presenting with bruising and abnormal platelet aggregation.
Area of Science:
- Hematology
- Pediatric Medicine
- Bleeding Disorders
Background:
- Acquired platelet dysfunction with eosinophilia (APDE) is a transient bleeding disorder characterized by marked eosinophilia.
- Also known as non-thrombocytopenic purpura with eosinophilia, it is frequently observed in children in Southeast Asia.
Observation:
- An 11-year-old male child presented with recent onset ecchymotic patches on his lower limbs.
- His hemogram showed elevated eosinophils with a normal platelet count.
- Coagulation screening indicated normal parameters, except for an increased bleeding time.
Findings:
- Platelet aggregation studies revealed normal aggregation with ristocetin.
- Reduced platelet aggregation was observed with adenosine diphosphate (ADP).
- No platelet aggregation occurred with collagen stimulation.
Implications:
- This case contributes to understanding the clinical presentation and diagnostic features of APDE in pediatric patients.
- Highlights the importance of platelet aggregation studies in diagnosing functional platelet disorders.
- Further research may elucidate the specific mechanisms underlying ADP and collagen hypo-responsiveness in APDE.
