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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
05:23

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

Published on: March 7, 2025

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H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis

Xianlong Ling1, Haoxiang Zhang1, Caifei Shen1

  • 1Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.

Infectious Agents and Cancer
|July 14, 2016
PubMed
Abstract

Insights

Helicobacter pylori infection correlates with mitochondrial microsatellite instability (mtMSI) and elevated IL-8 levels, suggesting a role in early gastric cancer development. These findings highlight mtMSI

Area of Science:

  • Gastroenterology and Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Investigating the link between Helicobacter pylori (H. pylori) infection and gastric carcinogenesis.
  • Examining the role of mitochondrial microsatellite instability (mtMSI) and Interleukin-8 (IL-8) in cancer development.

Purpose of the Study:

  • To determine the correlation between H. pylori infection, mtMSI, and IL-8 levels in gastric carcinogenesis.
  • To explore the potential involvement of IL-8 in H. pylori-induced mtMSI.

Main Methods:

  • H. pylori infection assessed via histology and urease breath test.
  • mtMSI measured using PCR-single strand conformation polymorphism (PCR-SSCP).
  • IL-8 levels analyzed using ELISA.

Main Results:

  • Significantly higher mtMSI rates in H. pylori-infected specimens (P < 0.05).
  • Significantly higher IL-8 levels in specimens with mtMSI (P < 0.01).
  • Association found between mtMSI and intestinal histological type (P < 0.05).
  • H. pylori-induced IL-8 elevations linked to invasion, lymph node spread, and clinical stage (P < 0.05).

Conclusions:

  • H. pylori infection is associated with mtMSI in early gastric cancer development.
  • IL-8 may mediate the development of H. pylori-induced mtMSI.
  • mtMSI plays a role in diverse gastric carcinogenesis mechanisms.
Keywords:
Gastric cancerH. pyloriIL-8Mitochondrial microsatellite instability

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