Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Hematopoiesis01:20

Overview of Hematopoiesis

11.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
11.1K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Teratogenicity01:07

Teratogenicity

4.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Rh Blood Group01:19

Rh Blood Group

4.1K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
4.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.3K
Hematopoiesis01:21

Hematopoiesis

9.6K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-transplantation Cyclophosphamide-based Graft-versus-host-disease Prophylaxis Compared to Methotrexate-cyclosporine a in Matched-related Allogeneic Hematopoietic Stem Cell Transplantation.

Hematology/oncology and stem cell therapy·2023
Same author

High Frequency of ASXL1 and IDH Mutations in Young Acute Myeloid Leukemia Egyptian Patients.

Asian Pacific journal of cancer prevention : APJCP·2022
Same author

LMP7 polymorphism may modify the presentation and clinical impact of minor histocompatibility antigens in matched related hematopoietic stem cell transplantation.

Cellular immunology·2021
Same author

The outcome of hematopoietic stem cell transplantation patients with COVID-19 infection.

Bone marrow transplantation·2020
Same author

Irradiation free conditioning regimen is associated with high relapse rate in Egyptian patients with acute lymphoblastic leukemia following allogeneic hematopoietic stem cell transplantation.

Journal of the Egyptian National Cancer Institute·2020
Same author

Outcome of Core Binding Factor Acute Myeloid Leukemia by Receptor Tyrosine Kinase Mutation.

Clinical lymphoma, myeloma & leukemia·2020

Related Experiment Video

Updated: Mar 18, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K

Hematologic malignancies during pregnancy: A review.

Hossam K Mahmoud1, Mohamed A Samra1, Gamal M Fathy2

  • 1Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt.

Journal of Advanced Research
|July 14, 2016
PubMed
Summary

Diagnosing hematologic cancers during pregnancy is challenging due to overlapping symptoms and imaging risks. Management requires balancing maternal and fetal health, considering treatment risks and patient preferences for pregnancy continuation.

Keywords:
Acute leukemiasChronic myeloid leukemiaHematologic malignanciesLymphomasPregnancy

More Related Videos

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

14.3K

Related Experiment Videos

Last Updated: Mar 18, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.6K
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

14.3K

Area of Science:

  • Oncology
  • Hematology
  • Obstetrics
  • Perinatology

Background:

  • Malignancy is a leading cause of death in reproductive-aged women, affecting approximately 1 in 1000 pregnancies.
  • Hematologic cancers during pregnancy are rare, leading to limited research and potential diagnostic delays.
  • Symptoms of hematologic malignancies can mimic normal pregnancy discomforts, complicating early detection.

Purpose of the Study:

  • To review diagnostic and management strategies for hematologic malignancies in pregnant patients.
  • To discuss the impact of these cancers and their treatments on both the mother and the developing fetus.
  • To highlight the challenges in diagnosing and treating these conditions during pregnancy.

Main Methods:

  • Review of current literature on hematologic malignancies diagnosed during pregnancy.
  • Analysis of diagnostic challenges, including imaging limitations and symptom overlap.
  • Evaluation of management strategies, considering maternal-fetal risks and patient autonomy.

Main Results:

  • Delayed or missed diagnoses are common due to non-specific symptoms and concerns about imaging safety.
  • Treatment decisions involve complex risk-benefit analyses for mother and fetus.
  • Patient preferences regarding pregnancy continuation are a critical factor in management.

Conclusions:

  • Hematologic malignancies in pregnancy necessitate a multidisciplinary approach, balancing cancer treatment with fetal well-being.
  • Further research is needed to improve diagnostic accuracy and optimize treatment protocols.
  • Individualized management plans are crucial, respecting patient values and preferences.