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Immunoglobulin G4-related pleuritis - A case report
Marta E Gajewska1, Beata A Rychwicka-Kielek2, Kathina Sørensen3
1Dept. of Respiratory Diseases and Allergy, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.
Respiratory Medicine Case Reports
|July 14, 2016
Summary
This case study highlights a rare instance of Immunoglobulin G4-related disease (IgG4-RD) affecting the pleura. Prompt diagnosis and immunosuppressive therapy led to patient improvement.
Area of Science:
- Immunology
- Pathology
- Radiology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a multisystemic fibroinflammatory condition.
- It is characterized by IgG4-positive plasma cell infiltration in affected tissues.
- Previous literature lacks extensive documentation on isolated IgG4-related pleural disease.
Observation:
- A rare case of IgG4-related pleural disease in a 58-year-old male is presented.
- The patient exhibited no other systemic manifestations of IgG4-RD.
- Diagnostic modalities included PET-CT imaging and histopathological analysis of a pleural specimen.
Findings:
- Characteristic PET-CT findings supported the diagnosis.
- Histopathology confirmed the presence of IgG4-positive plasma cells and lymphocytes.
- The pleural involvement was the sole presentation of the disease in this patient.
Implications:
- This case expands the known clinical spectrum of IgG4-related disease.
- It underscores the importance of considering IgG4-RD in cases of unexplained pleural thickening or effusion.
- Successful management with immunosuppressive therapy suggests a potential treatment pathway for this rare manifestation.
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