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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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[Association between ulcerative colitis and primary esclerosing cholangitis].

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This case report highlights a rare association between Ulcerative Colitis (UC) and Primary Sclerosing Cholangitis (PSC) in Peru. The patient experienced chronic diarrhea and liver enzyme abnormalities, leading to a dual diagnosis and successful treatment.

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Area of Science:

  • Gastroenterology and Hepatology
  • Clinical Case Study
  • Inflammatory Bowel Disease Research

Background:

  • Ulcerative Colitis (UC) is frequently associated with Primary Sclerosing Cholangitis (PSC), a rare liver disease.
  • The prevalence of PSC in UC patients in Latin America is notably low (2.9%).
  • This association is more common in UC than in Crohn's disease.

Observation:

  • A female patient presented with a year of chronic diarrhea, fever, oral ulcers, and weight loss.
  • Laboratory tests revealed elevated liver enzymes (alkaline phosphatase, GGT, ALT, AST) and an abdominal ultrasound showed hepatomegaly.
  • Colonoscopy confirmed Ulcerative Colitis, and MRCP diagnosed PSC associated with UC.

Findings:

  • The patient was treated with sulfasalazine, then prednisone and azathioprine due to an adverse reaction.
  • The patient achieved a favorable clinical outcome after treatment and discharge.
  • This represents the second reported case of UC associated with PSC in Peru, underscoring its rarity in the Southern Hemisphere.

Implications:

  • Reporting this rare case contributes to understanding the geographical and epidemiological variations of UC-PSC association.
  • Highlights the importance of investigating liver function in UC patients, especially with atypical presentations.
  • Adds valuable data to the limited literature on PSC in the South American population.