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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
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Deep brain stimulation for Parkinson's disease: current status and future outlook
Kyle A Smith1, Rajesh Pahwa2, Kelly E Lyons2
1Department of Neurosurgery, University of Kansas Medical Center, 3901 Rainbow Blvd, Mailstop 3021, Kansas City, KS 66160, USA.
Neurodegenerative Disease Management
|July 14, 2016
Summary
Deep brain stimulation offers significant symptom improvement for Parkinson's disease patients. Advances in surgical techniques and device technology continue to enhance treatment efficacy and patient outcomes.
Area of Science:
- Neurology
- Neurosurgery
- Biomedical Engineering
Background:
- Parkinson's disease involves the loss of dopaminergic neurons.
- Surgical therapy is an option for managing medication side effects or when additional treatment is required.
Purpose of the Study:
- To review advancements in deep brain stimulation for Parkinson's disease.
- To highlight improvements in surgical techniques and device technology.
Main Methods:
- Review of surgical innovations in deep brain stimulation (DBS).
- Discussion of technological enhancements in DBS hardware and functionality.
Main Results:
- Deep brain stimulation has shown improvement in cardinal parkinsonian signs.
- Surgical advances include frameless/mini-frame stereotactic systems and MRI-guided placement.
- Technological improvements include rechargeable generators and steerable stimulation.
Conclusions:
- Deep brain stimulation is a valuable adjunct therapy for Parkinson's disease.
- Ongoing research focuses on closed-loop 'smart' stimulation based on neuronal feedback.
