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Glomerular basement membrane thickness among the Saudi population.

Hala Kfoury1

  • 1a Department of Pathology and Laboratory Medicine , King Khalid University Hospital and College of Medicine, King Saud University , Riyadh , Saudi Arabia.

Ultrastructural Pathology
|July 14, 2016
PubMed
Summary

This study found that glomerular basement membrane (GBM) thickness in Saudi patients with minimal change disease increases with age up to 60 years but is not associated with gender. The average GBM thickness was 323.6 nm.

Keywords:
Glomerular basement membraneminimal change diseasethickness

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Area of Science:

  • Nephrology
  • Pathology
  • Medical research

Background:

  • Glomerular basement membrane (GBM) thickness is a key indicator in kidney health.
  • Understanding population-specific GBM thickness is crucial for diagnosing kidney diseases.
  • Minimal change disease (MCD) affects kidney function, and GBM characteristics are important.

Purpose of the Study:

  • To establish the mean glomerular basement membrane (GBM) thickness in the Saudi population.
  • To investigate the correlation between GBM thickness and demographic factors like age and gender in Saudi patients with MCD.
  • To compare findings with existing international literature.

Main Methods:

  • Ultrastructural analysis of at least three glomeruli per patient using electron microscopy with a digital camera.
  • Inclusion of 53 Saudi patients aged 2-70 years diagnosed with minimal change disease.
  • Calculation of mean GBM thickness and statistical analysis for gender and age group differences.

Main Results:

  • The mean GBM thickness across all Saudi patients was 323.6 ± 49.5 nm.
  • No significant difference in mean GBM thickness was observed between males and females.
  • A significant correlation was found between GBM thickness and age, with thickness increasing up to 60 years old.

Conclusions:

  • Mean GBM thickness in the Saudi population is comparable to global averages.
  • GBM thickness shows a direct proportionality with age up to 60 years in Saudi patients with MCD.
  • Gender does not appear to be a significant factor influencing GBM thickness in this cohort.