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Related Experiment Video

Updated: Mar 18, 2026

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

Published on: January 15, 2015

Variable spatial pattern probe based on offset launch of multimode waveguide for optogenetics.

Na Dong, Weifeng Jiang, Xiaohan Sun

|July 14, 2016

Summary

This summary is machine-generated.

Researchers developed a novel optical waveguide probe for optogenetics. This probe allows for variable spatial light patterns, enabling precise control over neural stimulation location in tissue.

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Last Updated: Mar 18, 2026

In vivo Optogenetic Stimulation of the Rodent Central Nervous System

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Published on: January 15, 2015

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

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Published on: December 27, 2013

Mapping the Cellular Distribution of an Optogenetic Protein Using a Light-Stimulation Grid

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Published on: January 26, 2024

Area of Science:

Optics and Photonics
Biomedical Engineering
Neuroscience

Background:

Optogenetics requires precise control over light delivery to neural tissue.
Existing methods for light delivery may lack spatial pattern variability.
Multi-mode optical waveguides offer potential for complex light manipulation.

Purpose of the Study:

To propose and experimentally demonstrate a variable spatial pattern probe for optogenetics.
To enable adjustable optical stimulation locations in neural tissue using micron-scale patterns.
To investigate the behavior of different light modes within the waveguide and tissue.

Main Methods:

Utilized coupling mode theory, Finite Element Method (FEM), and light diffusion Monte Carlo simulations.
Simulated mode patterns and their evolution for TE00, TE10, TE20, and TE11 modes.
Fabricated Silica-on-Silicon waveguide chips with varying widths and selectively excited specific modes.

Main Results:

Demonstrated the generation of variable spatial patterns at the waveguide output facet.
Experimental results for mode patterns and their evolution in tissue closely matched simulation predictions.
Confirmed the ability to change optical stimulating locations in neural tissue.

Conclusions:

The developed offset-launch multi-mode waveguide probe effectively generates variable spatial light patterns for optogenetics.
The probe offers precise control over stimulation location, advancing optogenetic applications.
The study validates simulation methods for predicting light propagation in waveguide-tissue systems.