Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Ill Fate of Rectal Mucinous Adenocarcinoma: A Defect in Immunosurveillance or a Mucin Coating Effect?-The IMMUNOREACT 20 Study.

Cancers·2026

Same author

Microplastics matter: practical implications of the EU REACH restriction for the pharmaceutical industry.

Frontiers in drug delivery·2026

Same author

Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Light-tunable DNA interactions enable spatiotemporal assembly and relaxation-driven crystallization of colloids.

Soft matter·2026

Same author

Light-induced physicochemical alterations of photoacid-containing nanogels allow spatiotemporal control over their cellular uptake.

Journal of controlled release : official journal of the Controlled Release Society·2026

Same author

Triple-junction solar cells with improved carrier and photon management.

Nature·2026

Same journal

Multicomponent Micelles with Boosted Stability of Iminoboronates.

Biomacromolecules·2026

Same journal

Stiffening and Toughening Protein Hydrogels by Tuning Electrostatic Interactions.

Biomacromolecules·2026

Same journal

<i>In Situ</i> Bulk and Interfacial Interlocking-Induced Highly Dynamically Entangled Hydrogel of Myocardium-Matching Mechanics, Electrophysiological Functions, and Robust Tissue Adhesion for Cardiac Repair.

Biomacromolecules·2026

Same journal

Eutectogel Electrodes with Self-powered Capability for Flexible Electrophysiological Sensor.

Biomacromolecules·2026

Same journal

Self-Reporting Supramolecular Coacervates Driven by Liquid-Liquid Phase Separation Enable Systemic Translocation and Photodynamic Bioprotection.

Biomacromolecules·2026

Same journal

Self-Assembed G-Quadruplex Nanowires for Energy Transfer over Micrometers.

Biomacromolecules·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 18, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Bundle Formation in Biomimetic Hydrogels.

Maarten Jaspers¹, A C H Pape², Ilja K Voets²

¹Radboud University , Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

Biomacromolecules

|July 14, 2016

Summary

This summary is machine-generated.

Polymer chain bundling creates unique biopolymer gels. Researchers studied synthetic polyisocyanide gels using small-angle X-ray scattering (SAXS) to mimic these biogels and understand their architecture and mechanical properties.

More Related Videos

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Published on: September 29, 2016

Related Experiment Videos

Last Updated: Mar 18, 2026

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Microwave-assisted Functionalization of Polyethylene glycol and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

Published on: October 29, 2013

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications

Published on: September 29, 2016

Area of Science:

Materials Science
Polymer Chemistry
Biophysics

Background:

Biopolymer networks, crucial for cellular functions, exhibit unique properties due to polymer chain bundling.
Synthetic hydrogels rarely replicate the large-pore formation and nonlinear mechanical responsiveness of biogels.
Polyisocyanide gels offer a synthetic model system to study biopolymer-like network formation.

Purpose of the Study:

To investigate the bundle formation and hydrogelation process in polyisocyanide gels.
To understand how concentration and polymer length influence gel architecture and mechanical properties.
To correlate structural parameters with mechanical behavior for designing synthetic biogel mimics.

Main Methods:

Small-angle X-ray scattering (SAXS) to analyze gel structure.
Mechanical testing to evaluate gel properties.
Varying polymer concentration and length to study their effects.

Main Results:

SAXS revealed structural changes at the gelation point.
Concentration and polymer length were identified as key factors determining gel architecture.
A correlation between gel mechanics and structural parameters was established.

Conclusions:

Polyisocyanide gels successfully mimic the bundled architecture and properties of biopolymer networks.
Understanding structure-property relationships is vital for developing advanced synthetic hydrogels.
This research provides a foundation for designing synthetic materials that replicate biological gel functions.