Related Experiment Video
Updated: Mar 18, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Sleep Disordered Breathing During Live High-Train Low in Normobaric Versus Hypobaric Hypoxia
Jonas J Saugy1,2, Laurent Schmitt3, Sibylle Fallet4
11 Faculty of Biology and Medicine, ISSUL, Institute of Sport Sciences, University of Lausanne , Switzerland .
Live high-train low (LHTL) altitude training using hypobaric hypoxia (HH) more significantly disrupts sleep and breathing compared to normobaric hypoxia (NH). Athletes experience greater breathing alterations and oxygen desaturation with HH during LHTL camps.
Area of Science:
- Sports Science
- Altitude Training
- Sleep Medicine
Background:
- Live high-train low (LHTL) is a training strategy used by athletes to enhance performance.
- Understanding the physiological effects of different hypoxia types during LHTL is crucial for optimizing training protocols.
- Sleep quality and breathing patterns are vital indicators of physiological adaptation to altitude.
Purpose of the Study:
- To compare sleep disordered breathing between normobaric hypoxia (NH) and hypobaric hypoxia (HH) during LHTL altitude camps.
- To assess the impact of NH versus HH on breathing frequency, oxygen saturation, and oxygen desaturation index in trained athletes.
- To determine which hypoxia simulation method leads to more significant sleep disturbances in an LHTL context.
Main Methods:
- Sixteen elite triathletes participated in two 18-day LHTL camps using a crossover design.
- Athletes trained at 1100-1200m while sleeping under either simulated normobaric hypoxia (2250m) or hypobaric hypoxia.
- Continuous monitoring of breathing frequency and oxygen saturation (SpO2), with calculation of the oxygen desaturation index (ODI 3%).
Main Results:
- Breathing frequency was significantly lower in NH (14.6 breaths/min) compared to HH (17.2 breaths/min).
- Oxygen saturation (SpO2) was lower in HH (90.8%) than in NH (91.9%).
- The oxygen desaturation index (ODI 3%) was significantly higher in HH (15.1) than in NH (9.9), indicating more frequent desaturations.
Conclusions:
- Sleep in moderate hypobaric hypoxia is more disruptive than in normobaric hypoxia during a live high-train low camp.
- Hypobaric hypoxia appears to induce more significant sleep-disordered breathing events compared to normobaric hypoxia.
- These findings suggest that the type of hypoxia simulation used in LHTL training can differentially affect sleep quality and respiratory patterns.
More Related Videos
Related Concept Videos
Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
Hyperpnea and Hyperventilation
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-IV
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...

