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Related Experiment Video

Updated: Mar 18, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
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Sub-wavelength grating for enhanced ring resonator biosensor.

Jonas Flueckiger, Shon Schmidt, Valentina Donzella

    Optics Express
    |July 14, 2016
    PubMed
    Summary
    This summary is machine-generated.

    This study engineered silicon photonic ring resonators using sub-wavelength gratings (SWG) for enhanced biosensing. The developed SWG ring resonator achieved high sensitivity and a low detection limit for biological assays.

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    Area of Science:

    • Photonics and Biosensing
    • Integrated Optics
    • Nanotechnology

    Background:

    • Silicon photonic resonant cavities are crucial for biosensing.
    • Improving sensitivity and detection limits remains a key research challenge.
    • Sub-wavelength gratings (SWG) offer a method to engineer optical properties.

    Purpose of the Study:

    • To engineer the effective refractive index and mode profile of silicon-on-insulator (SOI) waveguides.
    • To demonstrate the performance of SWG-engineered waveguides as biosensors.
    • To evaluate the sensitivity and detection limit of the developed biosensor.

    Main Methods:

    • Design of a 30 μm diameter SWG ring resonator.
    • Fabrication using electron beam (Ebeam) lithography.
    • Characterization of the resonator's quality factor (Q), bulk sensitivity (Sb), and system limit of detection (sLoD).

    Main Results:

    • Achieved a quality factor (Q) of 7 × 10³.
    • Measured a bulk sensitivity (Sb) of 490 nm/RIU (Refractive Index Unit).
    • Determined a system limit of detection (sLoD) of 2 × 10⁻⁶ RIU.

    Conclusions:

    • SWG engineering effectively modifies SOI waveguide properties for biosensing.
    • The fabricated SWG ring resonator demonstrates high performance for biosensing applications.
    • A model biological sandwich assay confirmed the biosensor's utility and sensitivity.