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Venous thromboembolism and subsequent permanent work-related disability
S K Braekkan1,2,3, S D Grosse4, E M Okoroh5
1K.G.Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway. sigrid.brakkan@uit.no.
Journal of Thrombosis and Haemostasis : JTH
|July 14, 2016
Summary
Venous thromboembolism (VTE) significantly increases the risk of permanent work-related disability. This suggests substantial indirect economic costs due to lost work time associated with VTE.
Area of Science:
- Medical research
- Public health
- Epidemiology
Background:
- The economic impact of venous thromboembolism (VTE) related to permanent work-related disability is not well understood.
- Previous research has not assessed this burden in a general population.
Purpose of the Study:
- To estimate the risk of work-related disability in individuals who have experienced a VTE compared to those who have not.
- To evaluate the association between VTE and subsequent permanent work-related disability.
Main Methods:
- A population-based cohort study involving 66,005 individuals aged 20-65 years from Norwegian health studies.
- Incident VTE events were identified and validated, with work-related disability data sourced from the Norwegian National Insurance Administration.
- Cox-regression models were used to estimate adjusted hazard ratios for work-related disability after VTE.
Main Results:
- The incidence rate of work-related disability was 37.5 per 1000 person-years after VTE, compared to 13.5 per 1000 person-years without VTE.
- Unprovoked VTE was associated with a 52% higher risk of work-related disability (HR, 1.52; 95% CI, 1.09-2.14) after multivariable adjustment.
- The association between VTE and disability appeared to be primarily driven by deep vein thrombosis.
Conclusions:
- Venous thromboembolism is linked to an increased risk of subsequent work-related disability in the general working-age population.
- The findings indicate that indirect costs from lost work time contribute significantly to the overall economic burden of VTE.
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