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Author Spotlight: Exploring Intrinsically Disordered Protein Dynamics Through NMR Relaxation Experiments
Published on: November 1, 2024
EXtended ACquisition Time (EXACT) NMR-A Case for 'Burst' Non-Uniform Sampling
Ikenna E Ndukwe1, Alexandra Shchukina2,3, Krzysztof Kazimierczuk2
1School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK.
Abstract:
A strong case exists for the introduction of burst non-uniform sampling (NUS) in the direct dimension of NMR spectroscopy experiments. The resulting gaps in the NMR free induction decay can reduce the power demands of long experiments (by switching off broadband decoupling for example) and/or be used to introduce additional pulses (to refocus homonuclear coupling, for example). The final EXtended ACquisition Time (EXACT) spectra are accessed by algorithmic reconstruction of the missing data points and can provide higher resolution in the direct dimension than is achievable with existing non-NUS methods.
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