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Updated: Mar 17, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
Modulation of chromatin function through linker histone H1 variants
Andrzej Kowalski1, Jan Pałyga1
1Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, 25-406 Kielce, Poland.
Abstract:
In this review, the structural aspects of linker H1 histones are presented as a background for characterization of the factors influencing their function in animal and human chromatin. The action of H1 histone variants is largely determined by dynamic alterations of their intrinsically disordered tail domains, posttranslational modifications and allelic diversification. The interdependent effects of these factors can establish dynamic histone H1 states that may affect the organization and function of chromatin regions.
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