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Anchoring Junctions

Anchoring Junctions

Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic

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Related Experiment Video

Updated: Mar 17, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

Nanocapillary Adhesion between Parallel Plates.

Shengfeng Cheng¹, Mark O Robbins²

¹Department of Physics, Center for Soft Matter and Biological Physics, and Macromolecules Innovation Institute, Virginia Polytechnic Institute and State University , Blacksburg, Virginia 24061, United States.

Langmuir : the ACS Journal of Surfaces and Colloids

|July 15, 2016

Summary

This summary is machine-generated.

Molecular dynamics simulations reveal that capillary adhesion deviates from macroscopic theory at separations below 5 nm due to molecular layering. Oscillations in the perpendicular pressure component significantly impact capillary adhesion at these small scales.

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Area of Science:

Surface science
Nanotechnology
Computational physics

Background:

Capillary adhesion is crucial in micro/nanoscale systems.
Macroscopic theories often assume continuum fluid behavior.

Purpose of the Study:

Investigate capillary adhesion at the nanoscale using molecular dynamics.
Compare simulation results with macroscopic theories.

Main Methods:

Molecular dynamics (MD) simulations.
Calculation of capillary force (Fcap) and meniscus shape.
Varying separation (h) between parallel solid surfaces.

Main Results:

Macroscopic theory accurately predicts meniscus shape and interfacial tension contribution for h > 1-2 nm.
Total capillary force deviates significantly from macroscopic theory for h ≲ 5 nm.
Molecular layering causes anisotropic pressure tensor and oscillations in the perpendicular component.

Conclusions:

Molecular layering is critical for understanding capillary adhesion at the nanoscale.
The perpendicular pressure component, influenced by layering, dictates capillary adhesion at small separations.