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Related Experiment Video

Updated: Mar 17, 2026

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Ethanol Consumption by Lactating Rats Induces Changes in Pup's Fatty Acid Profiles.

K T De Albuquerque¹, M D Do Carmo¹, E Herrera²

¹a Instituto de Nutriçāo , Universidade Federal do Rio de Janeiro , RJ , Brasil.

Nutritional Neuroscience

|July 15, 2016

Summary

This summary is machine-generated.

Maternal ethanol consumption during lactation alters milk fatty acid composition, leading to essential fatty acid deficiency in pups. These changes in brain phospholipids may contribute to abnormal pup development, independent of undernutrition.

Keywords:

Brain Breast milk Ethanol Fatty acids Lactation Phospholipids Pup's growth Rat

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Published on: December 16, 2015

Area of Science:

Nutritional Neuroscience
Developmental Toxicology
Lactational Pharmacology

Background:

Maternal ethanol consumption during lactation can impact offspring development.
Understanding the specific effects of ethanol on milk composition and subsequent pup neurodevelopment is crucial.

Purpose of the Study:

To investigate the effects of maternal ethanol intake on milk lipid composition and brain fatty acid profiles in lactating rats and their pups.
To determine if observed effects are due to ethanol or associated undernutrition.

Main Methods:

Lactating Wistar rats were divided into three groups: ethanol-fed (ET), pair-fed (PF), and control (C).
Milk and pup brain tissues were collected on day 12 of lactation for fatty acid analysis.
Pup body and brain weights were measured.

Main Results:

Ethanol-fed dams exhibited altered milk fatty acid profiles, with decreased C14:0 and C22:6 n-3, and increased C18:0, C16:1, and C18:1 n-9 compared to controls.
Pups from ethanol-fed dams showed lower body weight and evidence of essential fatty acid deficiency in brain phospholipids, indicated by an increased C20:3 n-9 to C20:4 n-6 ratio.
Decreased levels of essential fatty acids, including docosahexaenoic acid (C22:6 n-3), were observed in the brain phospholipids of pups from ethanol-fed dams, effects not solely attributable to undernutrition.

Conclusions:

Maternal ethanol intake during lactation significantly modifies milk lipid composition.
Ethanol exposure during lactation leads to essential fatty acid deficiency in rat pups' brain phospholipids.
These alterations in brain fatty acid composition may contribute to abnormal neurodevelopment in offspring exposed to ethanol in utero and during lactation.