Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

2.2K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
2.2K
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

2.8K
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
2.8K
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

2.4K
Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
2.4K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.0K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.0K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

2.3K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
2.3K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.4K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Building Intelligent ECG.

IEEE pulse·2026
Same authorSame journal

Benefits for Early Diagnosis, Treatment, and Research.

IEEE pulse·2026
Same author

Suite of Ingestible Devices Opens Window to the Gut Nervous System, Microbiome.

IEEE pulse·2026
Same author

Urine-Based Spectroscopy/AI Platform for Early Detection of Multiple Cancers.

IEEE pulse·2026
Same author

Results in a Week to a Month.

IEEE pulse·2026
Same author

From Promise to Practice: Building the Open Infrastructure for Health Wearables.

IEEE pulse·2026

Related Experiment Video

Updated: Mar 17, 2026

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
13:23

Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

Published on: February 20, 2012

20.5K

Thumbs Up for Stem Cells: Popular Reprogramming Methods Show No Systematic Mutations.

Leslie Mertz

    IEEE Pulse
    |July 15, 2016
    PubMed
    Summary

    Researcher Jeanne Loring is developing a stem cell therapy to reverse Parkinson's disease symptoms. The main concern is the safety of transplanting induced pluripotent stem cells (iPSCs) into patients.

    Area of Science:

    • Neuroscience
    • Regenerative Medicine
    • Stem Cell Biology

    Background:

    • Parkinson's disease (PD) is a progressive neurodegenerative disorder.
    • Current treatments manage symptoms but do not halt disease progression.
    • Stem cell therapies offer potential for neuroprotection and regeneration.

    Purpose of the Study:

    • To evaluate the safety of transplanting induced pluripotent stem cells (iPSCs) for Parkinson's disease treatment.
    • To address concerns regarding the potential risks associated with iPSC transplantation in patients.

    Main Methods:

    • Investigating the safety profile of induced pluripotent stem cells (iPSCs).
    • Assessing the potential risks and benefits of iPSC transplantation in a clinical context.

    More Related Videos

    Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
    10:52

    Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

    Published on: January 19, 2020

    11.5K
    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
    11:38

    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

    Published on: November 26, 2018

    11.2K

    Related Experiment Videos

    Last Updated: Mar 17, 2026

    Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts
    13:23

    Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts

    Published on: February 20, 2012

    20.5K
    Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method
    10:52

    Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

    Published on: January 19, 2020

    11.5K
    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
    11:38

    RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

    Published on: November 26, 2018

    11.2K

    Main Results:

    • The study is progressing smoothly, indicating positive initial developments.
    • Ongoing research focuses on ensuring the safety of iPSCs before clinical application.

    Conclusions:

    • Induced pluripotent stem cells (iPSCs) hold promise for Parkinson's disease therapy.
    • Ensuring the safety of iPSC transplantation is critical for clinical translation.