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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

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Inositol and Ginkgo biloba as Adjuncts in Chronic Depression: Case Report.

¹a Mental Health and Behavioral Science Service, VA Medical Center (116-A), 800 Zorn Avenue, Louisville , KY 40206 , USA.

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|July 15, 2016

Summary

This case report highlights the potential of inositol and ginkgo supplements as adjuncts for treating resistant depression when combined with bupropion. The combination therapy showed a notable reduction in depressive symptoms, suggesting inositol as a probable active agent.

Keywords:

Antidepressant Depression Ginkgo biloba Inositol

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Area of Science:

Neuroscience
Psychiatry
Nutritional Psychiatry

Background:

Treatment-resistant depression (TRD) poses a significant clinical challenge.
Traditional adjuncts like lithium and liothyronine (T3) have limitations.
Exploring novel adjuncts for depression management is crucial.

Purpose of the Study:

To report a case of chronic, treatment-resistant depression managed with bupropion and nutritional/herbal supplements.
To investigate the potential efficacy of inositol and ginkgo biloba as adjuncts to bupropion.
To review the role of inositol in mood disorders.

Main Methods:

A case report of a patient with dysthymic disorder unresponsive to multiple antidepressants.
Treatment involved bupropion combined with inositol and ginkgo biloba supplements.
Symptom severity assessed using the Hamilton Depression Rating Scale (Ham-D).

Main Results:

The patient showed a positive response to the combined therapy, with a reduction in Ham-D score from 17 to 11.
Bupropion dosage was successfully reduced while maintaining symptom improvement.
Inositol was hypothesized as the primary active adjunct for antidepressant effects, with ginkgo aiding cognition.

Conclusions:

Nutritional and herbal supplements, specifically inositol, may serve as effective adjuncts in managing resistant depression.
This case suggests a potential therapeutic role for inositol in mood regulation, warranting further investigation.
Combined therapy with bupropion, inositol, and ginkgo offers a promising avenue for treatment-resistant depression.