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Related Concept Videos

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Relapsed Acute Lymphoblastic Leukemia Presenting as Optic Neuritis.

S A Fadilah1, A A Raymond2, S K Cheong1

  • 1a Division of Hematology and Stem Cell Transplantation, Department of Medicine , Universiti Kebangsaan Malaysia (UKM) , Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur , Malaysia.

Hematology (Amsterdam, Netherlands)
|July 15, 2016
PubMed
Summary

Leukemic infiltration of the optic nerve is rare. Early diagnosis and prompt treatment are crucial for preserving vision in patients with acute lymphoblastic leukemia (ALL) ocular relapse.

Keywords:
Acute lymphoblastic leukemiaAcute visual lossFine-needle aspiration (FNA)Ocular leukemiaOptic neuritis

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Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Leukemic infiltration of the optic nerve is an uncommon but serious complication.
  • Prompt radiotherapy is recommended for optic nerve infiltration to preserve vision.
  • Ocular manifestations of leukemia can be misdiagnosed, leading to treatment delays.

Purpose of the Study:

  • To report a case of unilateral optic nerve relapse in a patient with acute lymphoblastic leukemia (ALL).
  • To highlight the challenges in early diagnosis and the impact on visual outcome.
  • To emphasize the need for effective diagnostic tools for ocular leukemia.

Main Methods:

  • Case report of a 17-year-old male diagnosed with ALL.
  • Description of unilateral optic nerve relapse occurring 7 months post-diagnosis.
  • Review of initial misdiagnosis as optic neuritis and subsequent treatment with corticosteroids and radiation therapy.

Main Results:

  • The patient experienced a unilateral optic nerve relapse of ALL.
  • Initial misdiagnosis as optic neuritis led to delayed appropriate treatment.
  • Radiation therapy initiated 2 months after symptom onset failed to restore vision.
  • Lack of early diagnostic tools resulted in poor visual outcome.

Conclusions:

  • Optic nerve relapse in ALL can occur even after treatment cessation.
  • Early and accurate diagnosis of ocular leukemia is critical for effective management.
  • Delayed diagnosis and treatment significantly impair visual prognosis.