Related Experiment Video
Updated: Mar 17, 2026

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
Published on: October 2, 2018
Caffeine Withdrawal and Headaches
1a Department of Experimental Psychology , University of Bristol , 8 Woodland Road, Bristol BS8 1TN , UK.
Abstract:
Previous research has shown that cessation of caffeine consumption may be associated with a distinct withdrawal syndrome, typified by an increase in headaches. Recent research suggests that low to moderate consumers of caffeine may report an increase in headaches if they perceive caffeine to have been withdrawn regardless of whether it has been or not. The present study provides additional support for the role of subjective perceptions in the caffeine withdrawal syndrome. Forty-three low caffeine consumers recorded the incidence of headaches when drinking caffeinated or decaffeinated beverages. When caffeine was withdrawn the incidence of headaches increased but this effect was only significant in those individuals who could discriminate whether they were consuming caffeinated or decaffeinated beverages. This result suggests a major role of subjective perceptions and expectancies in the caffeine withdrawal syndrome, a view that contrasts with the notion that a significant proportion of caffeine consumers are physically dependent upon caffeine.
More Related Videos
Related Concept Videos
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
CNS Depressants: Alcohol and Nicotine
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
CNS Depressants: Barbiturates and Benzodiazepines
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

