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Related Concept Videos

Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Mar 17, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
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Cytokines in Platelet Concentrates.

N M Heddle1

  • 1a Department of Pathology , McMaster University and Laboratory Medicine, Hamilton Health Sciences Corporation , Hamilton , Ontario , Canada.

Hematology (Amsterdam, Netherlands)
|July 15, 2016
PubMed
Summary
This summary is machine-generated.

Proinflammatory cytokines increase in stored platelet concentrates, potentially causing febrile non-hemolytic transfusion reactions. Further research is needed to clarify the role of other stored cytokines in transfusion medicine.

Keywords:
Cytokinesadverse effectsplatelet concentratestransfusion

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Area of Science:

  • Transfusion Medicine
  • Immunology
  • Hematology

Background:

  • Cytokines, including proinflammatory cytokines, chemokines, and transforming growth factor β, increase in platelet concentrates during storage.
  • Cytokine concentrations vary based on preparation methods and product composition (leukocyte/platelet counts).

Purpose of the Study:

  • To investigate the clinical significance of cytokines accumulating in stored platelet products.
  • To determine the role of proinflammatory cytokines in febrile non-hemolytic transfusion reactions (FNHTR).

Main Methods:

  • Review of correlational, observational, and experimental studies examining cytokine levels and transfusion reactions.
  • Analysis of factors influencing cytokine accumulation in platelet concentrates.

Main Results:

  • High concentrations of proinflammatory cytokines are associated with increased frequency of FNHTR.
  • Platelet products with higher leukocyte counts correlate with a greater likelihood of causing FNHTR.
  • Products with low cytokine levels rarely cause FNHTR.

Conclusions:

  • Clinical data suggest proinflammatory cytokines play a significant role in FNHTR.
  • The clinical relevance of chemokines and other growth factors in platelet concentrates remains inconclusive.
  • Further investigation is warranted to fully understand the impact of stored cytokines on transfusion outcomes.