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Gender specific differences in patients with psoriatic arthritis
Kemal Nas1, Erhan Capkin2, Abdullah Zübeyir Dagli3
1a Division of Rheumatology and Immunology, Department of Physical Medicine and Rehabilitation , Sakarya University, Faculty of Medicine , Sakarya , Turkey.
Modern Rheumatology
|July 15, 2016
Summary
Gender influences psoriatic arthritis (PsA) presentation. Women experience higher disease activity and fatigue, while men show greater skin involvement (PASI). Quality of life and joint patterns are similar across genders.
Area of Science:
- Rheumatology
- Dermatology
- Clinical Research
Background:
- Psoriatic arthritis (PsA) is a chronic inflammatory condition affecting joints and skin.
- Understanding gender-specific differences in PsA is crucial for tailored patient management.
Purpose of the Study:
- To investigate and delineate gender-related variations in clinical, radiological, and laboratory features of psoriatic arthritis patients.
Main Methods:
- A cohort of consecutively recruited PsA patients underwent standardized clinical, radiological, and laboratory assessments.
- Data collection utilized standardized protocols and case report forms for consistency.
Main Results:
- Women with PsA reported longer symptom duration, higher BMI, more tender/swollen joints, elevated DAS28 and ESR, and greater fatigue and physical limitations.
- Men exhibited higher Psoriasis Area and Severity Index (PASI) scores.
- Quality of life, articular patterns, and extra-articular features were comparable between genders.
Conclusions:
- Significant gender-based differences exist in PsA presentation, particularly in disease activity, fatigue, and skin severity.
- While quality of life and joint involvement show similarities, men are prone to higher PASI scores, and women report more pronounced disease activity and functional limitations.
