Related Experiment Video
Updated: Mar 17, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
Therapeutic Modulation of Aortic Stiffness
Ahmed Muzhir Hussein1, Ghazwan Shaaya, Rohit Arora
11Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX; 2Captain James A. Lovell Hospital, North Chicago, IL; 3Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL; and 4Northern Illinois University.
Abstract:
Aortic stiffness (AS) is an important predictor of cardiovascular morbidity in humans. The present review discusses the possible pathophysiological mechanisms of AS and focuses on a survey of different therapeutic modalities for decreasing AS. The influence of several nonpharmacological interventions is described: decrease body weight, diet, aerobic exercise training, music, and continuous positive airway pressure therapy. The effects of different pharmacological drug classes on AS are also discussed: antihypertensive drugs-renin-angiotensin-aldosterone system drugs, beta-blockers, alpha-blockers, diuretics, and calcium channel blockers (CCBs)-advanced glycation end product cross-link breakers, statins, oral anti-diabetics, anti-inflammatory drugs, vitamin D, antioxidant vitamins, and endothelin-1 receptor antagonists. All of these have shown some effect in decreasing AS.
Related Concept Videos
Aortic Regurgitation III: Medical Management
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Atherosclerosis III: Management
Aortic Regurgitation IV: Nursing Management
Mitral Stenosis III: Medical Management
Aortic Regurgitation I: Introduction

