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Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Esophagus01:24

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The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
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Deglutition01:25

Deglutition

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Swallowing, otherwise known as deglutition, facilitates the transport of food from the mouth to the stomach. It is a multifaceted process that involves both the tongue and the muscles of the throat and esophagus. Saliva and mucus aid in this process, which takes approximately 4 to 8 seconds for semi-solid or solid food and around 1 second for liquids or very soft food.
Swallowing can be divided into three stages: the voluntary phase, the pharyngeal phase, and the esophageal phase. Although the...
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Gastric Motility01:16

Gastric Motility

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Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
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Physiology of the Gastrointestinal System I: Ingestion and Propulsion01:22

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

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The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.
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Esophageal Achalasia01:27

Esophageal Achalasia

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Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...
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Related Experiment Video

Updated: May 6, 2026

Gastrointestinal Motility Monitor GIMM
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Intraluminal pH esophageal motility.

E Corazziari, C Pozzessere, S Dani

    Gastroenterology
    |August 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Lower esophageal body motor activity is sensitive to intraluminal pH. Acidic conditions (pH 4-2) trigger esophageal responses with smaller liquid volumes compared to neutral pH.

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    Area of Science:

    • Gastroenterology
    • Physiology
    • Esophageal Function

    Background:

    • The esophagus plays a crucial role in transporting food and liquids to the stomach.
    • Understanding the factors influencing esophageal motor activity is vital for diagnosing and treating esophageal disorders.
    • Intraluminal pH is a potential modulator of esophageal motility.

    Purpose of the Study:

    • To investigate the impact of varying intraluminal pH levels on the motor activity of the lower esophageal body.
    • To determine the threshold pH that elicits a significant motor response in the esophagus.

    Main Methods:

    • 14 healthy subjects underwent manometric recording of esophageal motor activity.
    • Liquid boluses with controlled pH values (ranging from 7 to 2) were infused into the esophagus.
    • Esophageal motor responses, including secondary peristalsis and simultaneous contractions, were analyzed.

    Main Results:

    • All tested pH levels elicited esophageal motor responses.
    • Secondary peristalsis was induced by similar volumes at pH 7, 6, and 5.
    • Significantly smaller volumes were required to elicit secondary peristalsis at pH 4, 3, and 2, indicating increased sensitivity to acidity. Simultaneous contractions were unaffected by the tested pH range.

    Conclusions:

    • The motor activity of the lower esophageal body is sensitive to intraluminal pH.
    • Acidic conditions (pH 4-2) significantly lower the volume threshold required to elicit secondary peristalsis.
    • Intraesophageal pH does not appear to affect simultaneous motor activity within the studied range.