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Autism and Schizophrenia: Intestinal Disorders.

R Cade1, M Privette1, M Fregly1

  • 1a Departments of Medicine, Physiology, Psychology and Psychiatry , University of Florida , Gainesville , FL 32610-0204 , USA.

Nutritional Neuroscience
|July 15, 2016
PubMed
Summary
This summary is machine-generated.

This study suggests that schizophrenia and autism may be linked to exorphins from gluten and casein. Dietary changes, like a gluten-casein-free diet, showed significant improvements in patients with these conditions.

Keywords:
AutismCaseinDietGliadorphinGlutenSchizophreniaβ-Casomorphin

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Immunology

Background:

  • Dohan's hypothesis links schizophrenia to gluten and casein exorphins.
  • Previous research explored these links in autism.

Purpose of the Study:

  • To investigate the association between gluten/casein exorphins and schizophrenia/autism.
  • To assess the impact of a gluten-casein-free diet on these conditions.

Main Methods:

  • Molecular screening (Sephadex G-15) for peptide peaks.
  • Immunoglobulin (IgA, IgG) assays for gliadin and casein antibodies.
  • Clinical observation of patients on dietary interventions.

Main Results:

  • Elevated IgG antibodies to gliadin and casein found in 86-93% of patients.
  • High IgA antibodies to gluten/casein detected in 30-87% of patients.
  • Gluten-casein-free diet improved behavior in 81% of autistic children and reduced symptoms in schizophrenic patients.

Conclusions:

  • Data support the exorphin hypothesis for schizophrenia and autism.
  • Incomplete digestion of gluten and casein may lead to exorphin absorption.
  • Dietary interventions show promise for managing these neurodevelopmental disorders.