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Autism and Schizophrenia: Intestinal Disorders
R Cade1, M Privette1, M Fregly1
1a Departments of Medicine, Physiology, Psychology and Psychiatry , University of Florida , Gainesville , FL 32610-0204 , USA.
Nutritional Neuroscience
|July 15, 2016
Summary
This study suggests that schizophrenia and autism may be linked to exorphins from gluten and casein. Dietary changes, like a gluten-casein-free diet, showed significant improvements in patients with these conditions.
Area of Science:
- Neuroscience
- Gastroenterology
- Immunology
Background:
- Dohan's hypothesis links schizophrenia to gluten and casein exorphins.
- Previous research explored these links in autism.
Purpose of the Study:
- To investigate the association between gluten/casein exorphins and schizophrenia/autism.
- To assess the impact of a gluten-casein-free diet on these conditions.
Main Methods:
- Molecular screening (Sephadex G-15) for peptide peaks.
- Immunoglobulin (IgA, IgG) assays for gliadin and casein antibodies.
- Clinical observation of patients on dietary interventions.
Main Results:
- Elevated IgG antibodies to gliadin and casein found in 86-93% of patients.
- High IgA antibodies to gluten/casein detected in 30-87% of patients.
- Gluten-casein-free diet improved behavior in 81% of autistic children and reduced symptoms in schizophrenic patients.
Conclusions:
- Data support the exorphin hypothesis for schizophrenia and autism.
- Incomplete digestion of gluten and casein may lead to exorphin absorption.
- Dietary interventions show promise for managing these neurodevelopmental disorders.
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