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Related Concept Videos

Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
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Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
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Peptic Ulcer Disease IV: Management01:26

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Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
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Pharmacological management
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Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents01:20

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The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

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Updated: Mar 17, 2026

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
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Fibrin Glue for Bleeding Peptic Ulcers.

L Langmead1, P Swain1

  • 1a Royal London Hospital , Whitechapel, London E1 1BB.

Hematology (Amsterdam, Netherlands)
|July 15, 2016
PubMed
Summary

Fibrin tissue glue, a plasma-derived product, effectively treats bleeding peptic ulcers. Repeated injections significantly reduced rebleeding rates compared to single sclerosant injections in a large trial.

Area of Science:

  • Gastroenterology
  • Surgical Hemostasis

Background:

  • Fibrin glue is a plasma-derived hemostatic agent.
  • It is administered via endoscopic injection for bleeding peptic ulcers.
  • Previous studies suggested efficacy with minimal tissue damage.

Purpose of the Study:

  • To evaluate the efficacy of repeated fibrin tissue glue injections versus single sclerosant injections for bleeding peptic ulcers.

Main Methods:

  • A large randomized trial involving 854 patients with bleeding peptic ulcers.
  • Patients received either repeated fibrin tissue glue injections or a single injection of polidocanol.
  • Endoscopic assessment was used to identify active bleeding or visible vessels.

Main Results:

Keywords:
Fibrin glueadrenalinebleeding ulcerendoscopic therapyendoscopyinjectionpolidocanolrandomized trial

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  • Repeated fibrin tissue glue injections demonstrated a significantly lower rebleeding rate.
  • Comparison was made against single injections of the sclerosant polidocanol.

    • Conclusions:

    • Repeated endoscopic application of fibrin tissue glue is a superior treatment strategy for bleeding peptic ulcers.
    • This approach offers improved outcomes in terms of reduced rebleeding.