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Related Experiment Video

Updated: Mar 17, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid

Published on: November 1, 2024

Topical retinoids for acne.

Lindsey Yeh¹, Lauren Meshkov Bonati¹, Nanette B Silverberg^1,2

¹Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Seminars in Cutaneous Medicine and Surgery

|July 15, 2016

Summary

This summary is machine-generated.

Topical retinoids are FDA-approved for acne vulgaris treatment in patients 12+. They effectively reduce lesions and improve acne severity, remaining a first-line therapy despite potential side effects like dryness and peeling.

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Area of Science:

Dermatology
Pharmacology

Background:

Topical retinoids are FDA-approved for acne vulgaris treatment.
They are indicated for nonpregnant, nonlactating patients aged 12 years and older.
Their efficacy and safety profiles are well-established.

Purpose of the Study:

To review the efficacy, safety, and tolerability of topical retinoids for acne vulgaris.
To highlight their role as a first-line treatment option.

Main Methods:

Literature review of studies on topical retinoid use in acne vulgaris.
Analysis of clinical trial data regarding lesion count, severity, and cosmetic appearance.
Assessment of reported side effects and tolerability.

Main Results:

Topical retinoids demonstrate significant reduction in inflammatory and noninflammatory acne lesions.
Studies confirm improvement in acne severity and cosmetic appearance.
Common side effects include erythema, peeling, and dryness, with variability among products.

Conclusions:

Topical retinoids are highly effective and safe for managing acne vulgaris.
They represent a cornerstone first-line treatment due to consistent positive outcomes.
Patient counseling regarding potential side effects is crucial for adherence.