Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radical Autoxidation01:20

Radical Autoxidation

3.3K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.3K
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

5.1K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
5.1K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.5K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.5K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

19.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.4K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

894
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
894
Aging01:26

Aging

964
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
964

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary intake of older patients in hospital and at home: the validity of patient kept food diaries.

The journal of nutrition, health & aging·2008
Same author

Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke.

European journal of clinical nutrition·2005
Same author

Refeeding syndrome: life-threatening, underdiagnosed, but treatable.

QJM : monthly journal of the Association of Physicians·2005
Same author

Potentially treatable causes of poor outcome in acute stroke patients with urinary incontinence.

Acta neurologica Scandinavica·2003
Same author

Antioxidant capacity after acute ischaemic stroke.

QJM : monthly journal of the Association of Physicians·2002
Same author

Iatrogenic causes of falls in hospitalised elderly patients: a case-control study.

Postgraduate medical journal·2002

Related Experiment Video

Updated: Mar 17, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

38.3K

Oxidative Damage, Antioxidants and Stroke.

S E Gariballa1

  • 1a Sheffield Institute for Studies on Ageing, The University of Sheffield, Barnsley General Hospital , Gawber Road, Barnsley S75 2EP , UK.

Nutritional Neuroscience
|July 15, 2016
PubMed
Summary

Dietary intake of fruits, vegetables, and grains may reduce stroke risk. Low antioxidant levels are linked to increased stroke incidence, suggesting a potential neuroprotective role for antioxidants in brain injury.

Keywords:
AntioxidantsFree radicalsIschaemiaOxidative damageStroke

More Related Videos

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage
12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

6.8K
Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research
06:35

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research

Published on: March 29, 2024

1.3K

Related Experiment Videos

Last Updated: Mar 17, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
11:05

Analysis of Oxidative Stress in Zebrafish Embryos

Published on: July 7, 2014

38.3K
Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage
12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

6.8K
Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research
06:35

Author Spotlight: Innovative Techniques for ROS Detection and Implications for Platelet Research

Published on: March 29, 2024

1.3K

Area of Science:

  • Nutrition science
  • Neurology
  • Cardiovascular research

Background:

  • Epidemiological studies suggest diets rich in fruits, vegetables, and grains are associated with lower mortality, especially from cardiovascular disease.
  • Low plasma antioxidant concentrations have been consistently linked to an increased risk of stroke.
  • Free radical production is implicated as a significant mechanism in brain injury following ischemia and reperfusion.

Purpose of the Study:

  • To explore the role of nutritional factors in stroke incidence and treatment.
  • To investigate the association between dietary patterns, antioxidant levels, and stroke risk.
  • To examine the potential neuroprotective effects of antioxidants against ischemic brain damage.

Main Methods:

  • Review of epidemiological studies on diet and stroke risk.
  • Analysis of studies investigating plasma antioxidant concentrations and stroke incidence.
  • Examination of evidence regarding free radical formation in ischemic brain injury.

Main Results:

  • Higher consumption of fruits, vegetables, and grains correlates with reduced mortality risk.
  • Consistent findings indicate a link between low antioxidant levels and elevated stroke risk.
  • Indirect evidence supports the role of free radicals in ischemic brain injury.

Conclusions:

  • Nutritional factors, particularly antioxidants from fruits, vegetables, and grains, may play a role in stroke prevention.
  • The precise role of free radical formation and antioxidant neuroprotection in ischemic stroke pathogenesis requires further investigation.