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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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Zinc Deprivation and the Nervous System.

B L O'dell1, J D Browning1

  • 1a Department of Biochemistry, 112 Animal Science Research Center , University of Missouri , Columbia , MO 65211 , USA.

Nutritional Neuroscience
|July 15, 2016
PubMed
Summary
This summary is machine-generated.

Dietary zinc deprivation causes neurological issues, including behavioral changes and neuropathy. Early signs suggest a protective role for vulnerable zinc pools against oxidative damage in nerve cells.

Keywords:
BehaviorCalcium uptakeChelatable zincDietary zincFood intakePlasma and synaptic membrane function

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Area of Science:

  • Neuroscience
  • Nutritional Biochemistry

Background:

  • Zinc is crucial for nervous system function.
  • Zinc deficiency rapidly induces pathological signs in animals.
  • The precise biochemical mechanisms of zinc deficiency in the nervous system are not fully understood.

Purpose of the Study:

  • To review the role of zinc in nervous system function.
  • To emphasize the effects of dietary zinc deprivation on neurological health.
  • To identify potential limiting zinc pools and their functions.

Main Methods:

  • Review of existing literature on zinc metabolism and neurological function.
  • Analysis of pathological signs and behavioral changes associated with zinc deficiency.
  • Examination of zinc-dependent proteins and zinc pools in neural tissue.

Main Results:

  • Zinc deficiency leads to behavioral changes, abnormal stance, and peripheral neuropathy.
  • Essential zinc metalloproteins remain stable during early deficiency.
  • Candidate limiting zinc pools include 'chelatable' and plasma membrane pools.
  • Zinc deficiency affects calcium uptake in synaptosomes and may impair protective mechanisms against oxidative damage.

Conclusions:

  • The initial limiting role of zinc in nerve tissue may be protective against oxidative damage, particularly to plasma membrane proteins and calcium channels.
  • This protective role is distinct from catalytic or neurotransmitter functions.
  • Further research is needed to identify specific zinc-dependent proteins affected early in deficiency.