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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line

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Published on: May 10, 2017

Interleukin-11 Gene Expression in Human Lymphoid Malignancy.

G Ishii¹, K Harigaya¹, Y W Qiang¹

¹a Department of Pathology , Chiba University , Chiba , Japan.

Hematology (Amsterdam, Netherlands)

|July 15, 2016

Summary

This summary is machine-generated.

Interleukin-11 (IL-11) transcripts are present in some lymphoid malignancies, like follicular lymphoma, but not secreted as active protein. This suggests IL-11 gene expression may be altered during lymphoid cell neoplastic transformation.

Keywords:

Interleukin-11 constitutive expression human lymphoid malignancy

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Last Updated: Mar 17, 2026

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Published on: February 21, 2018

Area of Science:

Immunology
Molecular Biology
Oncology

Background:

Interleukin-11 (IL-11) shares functions with IL-6 in hematopoiesis.
Limited data exists on IL-11 expression in lymphoid malignancies.

Purpose of the Study:

To investigate the expression of IL-11 in lymphoid cell lines and malignant lymphoma.
To explore the regulation of IL-11 transcript levels in lymphoid cells.

Main Methods:

Reverse transcriptase polymerase chain reaction (RT-PCR) to detect IL-11 transcripts.
Northern blotting for IL-11 expression analysis.
IL-11 bioassay and ELISA to assess protein secretion.

Main Results:

IL-11 transcripts detected in multiple lymphoid cell lines, notably high in follicular lymphoma (FL18).
IL-11 transcript levels in FL18 were constitutive and not upregulated by stimulation, unlike bone marrow stromal cells (KM102).
FL18 cells did not secrete biologically active IL-11; transcript stability was similar in FL18 and KM102.

Conclusions:

IL-11 transcripts can be found in neoplastic lymphoid cells, including malignant lymphoma.
Constitutive IL-11 expression in FL18 suggests potential alterations in gene regulation during lymphoid cell transformation.
Further research is needed to understand the role of IL-11 in lymphoid malignancies.