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Imaging modalities in Focal Therapy: Multiparametric Ultrasound.

R R Wildeboer1, A P Panfilova1, M Mischi1

  • 1Biomedical Diagnostics Lab. Electrical Engineering Dept. Eindhoven University of Technology. The Netherlands.

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Multiparametric ultrasound (mpUS) shows promise for guiding focal therapy in prostate cancer (PCa) by improving lesion detection and localization. Further research is needed to optimize mpUS for effective organ-sparing treatments.

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Area of Science:

  • Urology
  • Medical Imaging
  • Oncology

Background:

  • Prostate cancer (PCa) is a leading cause of cancer death in men.
  • Over-treatment of low-risk PCa with radical prostatectomy is a concern.
  • Focal therapy offers an organ-sparing alternative, but requires reliable imaging.

Purpose of the Study:

  • To review the potential of multiparametric ultrasound (mpUS) for guiding focal therapy in PCa.
  • To assess the capabilities of various ultrasound modalities for PCa detection and localization.

Main Methods:

  • Review of common focal therapies and their imaging requirements.
  • Discussion of ultrasound modalities including greyscale, Doppler, elastography, contrast-enhanced, and computerized ultrasound.
  • Evaluation of ultrasound techniques for localizing PCa and reflecting tissue properties.

Main Results:

  • Several ultrasound modalities are used clinically for PCa diagnosis and treatment monitoring.
  • No single ultrasound modality is currently sufficient for stand-alone tumor detection and localization.
  • Combined mpUS approaches show promising results for improved PCa detection and localization.

Conclusions:

  • Ultrasound modalities can monitor tissue destruction during and after focal therapy.
  • mpUS demonstrates potential for enhanced PCa detection and localization.
  • Further investigation of mpUS for therapeutic applications is recommended.