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Updated: Mar 17, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Avanafil for the treatment of erectile dysfunction
Jonathan L Zurawin1, Carrie A Stewart1, James E Anaissie1
1a Department of Urology , Tulane University School of Medicine , New Orleans , LA , USA.
Avanafil, a second-generation phosphodiesterase-5 (PDE5) inhibitor, offers a safe and effective treatment for erectile dysfunction (ED). It provides a faster onset of action and fewer side effects compared to older ED medications.
Area of Science:
- Urology
- Pharmacology
Background:
- Erectile dysfunction (ED) prevalence is increasing globally with aging populations.
- First-generation phosphodiesterase-5 (PDE5) inhibitors revolutionized ED treatment but have drawbacks.
- Avanafil represents a second-generation PDE5 inhibitor offering an improved therapeutic option.
Purpose of the Study:
- To review the literature on Avanafil, a second-generation PDE5 inhibitor.
- To evaluate the efficacy and tolerability of Avanafil in treating erectile dysfunction.
- To compare Avanafil's profile with existing ED treatments.
Main Methods:
- Literature review of current studies on Avanafil.
- Analysis of pivotal clinical trials assessing efficacy and tolerability.
- PubMed database search for articles on Avanafil's clinical trials, pharmacokinetics, safety, and efficacy.
Main Results:
- Avanafil is a safe and efficacious treatment for erectile dysfunction.
- Its unique pharmacologic profile minimizes side effects.
- Avanafil demonstrates a reduced time of onset of action compared to competitors.
Conclusions:
- Avanafil offers a significant advancement in oral ED therapy.
- The drug enhances treatment options for men with erectile dysfunction.
- Avanafil promotes a more spontaneous sex life for patients with ED.
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