Disabled-2: A modular scaffold protein with multifaceted functions in signaling
Carla V Finkielstein1, Daniel G S Capelluto2
1Integrated Cellular Responses Laboratory, Department of Biological Sciences, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA.
Summary
Disabled-2 (Dab2) protein modulates cell interactions and signaling pathways. This review details Dab2
Area of Science:
- Cell Biology
- Molecular Signaling
- Protein Function
Background:
- Disabled-2 (Dab2) is a scaffold protein involved in cell growth, differentiation, and homeostasis.
- Its role in cell-cell interactions is increasingly recognized but not fully understood.
Purpose of the Study:
- To provide a comprehensive analysis of Dab2's mechanisms in mediating cell-cell interactions.
- To highlight Dab2's function in cell signaling and development.
Main Methods:
- Literature review of existing studies on Dab2 function.
- Analysis of Dab2's interactions with integrin receptors, cell surface lipids, and endocytic machinery.
Main Results:
- Dab2 regulates platelet aggregation by interacting with integrin receptors (blocking inside-out and modulating outside-in signaling).
- Dab2 associates with cell surface lipids, influencing cell-cell interaction extent.
- Dab2 mediates endocytosis via interactions with specific motifs, phosphoinositides, and clathrin.
Conclusions:
- Dab2 is a multifaceted regulator of cell signaling, cell-cell interactions, and endocytosis.
- Emerging roles in tissue development and immune responses underscore Dab2's broad physiological significance.
Keywords:
Disabled-2adaptor proteinendocytosisphosphatidylinositol 4,5-bisphosphateplateletssulfatidestumor suppressorMore Related Videos
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