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Specific Labeling of Mitochondrial Nucleoids for Time-lapse Structured Illumination Microscopy

Specific Labeling of Mitochondrial Nucleoids for Time-lapse Structured Illumination Microscopy

Published on: June 4, 2020

Nanostructured luminescently labeled nucleic acids.

Larry J Kricka¹, Paolo Fortina^2,3, Jason Y Park⁴

¹Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA.

Luminescence : the Journal of Biological and Chemical Luminescence

|July 16, 2016

Summary

This summary is machine-generated.

This review explores novel methods for labeling nucleic acids with luminescent nanomaterials. It covers three key trends in creating luminescently labeled nucleic acid nanostructures for advanced applications.

Keywords:

chemiluminescence electrochemiluminescence nanostructures nucleic acid labeling photoluminescence

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Area of Science:

Biotechnology
Nanotechnology
Materials Science

Background:

Luminescence and nucleic acids are key components in developing novel nanomaterials.
Nanotechnology offers advanced tools for labeling and functionalizing nucleic acids.

Purpose of the Study:

To review emerging trends in luminescently labeled nucleic acids.
To cover three distinct approaches in this interdisciplinary field.

Main Methods:

Conventional luminescence labeling of nucleic acid nanostructures.
Labeling bulk nucleic acids with nanostructured luminescent labels.
Labeling nucleic acid nanostructures with nanostructured luminescent labels.

Main Results:

Advances in direct and indirect labeling methods are presented.
The review consolidates recent progress in three key areas.
Successful generation of nanostructured luminescently labeled nucleic acids.

Conclusions:

The integration of luminescence, nucleic acids, and nanotechnology is a rapidly advancing field.
These methods enable the creation of sophisticated nanoprobes.
Future applications span diagnostics, imaging, and synthetic biology.