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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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Integrative Pediatrics: Looking Forward.

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Pediatric illness patterns are shifting, increasing demand for preventative care. Pediatric integrative medicine, a holistic approach, is emerging to meet these evolving healthcare needs.

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Area of Science:

  • Pediatrics
  • Integrative Medicine
  • Preventative Health

Background:

  • The prevalence of pediatric diseases and illnesses is increasing, altering the scope of pediatric practice.
  • There is a growing demand for pediatricians with enhanced skills focused on preventative health strategies.
  • Shifting illness patterns in children necessitate advancements in pediatric care.

Discussion:

  • Integrative medicine in pediatrics is defined as healing-oriented care considering the whole child, including lifestyle and family health.
  • This approach is evidence-informed, evaluating all appropriate treatment modalities.
  • It addresses the need for a comprehensive approach to child health.

Key Insights:

  • The field of pediatric integrative medicine is rapidly advancing.
  • Expert clinicians contribute to the educational advancement of this field.
  • This Special Issue highlights evidence-based integrative topics in pediatrics.

Outlook:

  • Increased awareness of integrative topics with strong evidence is crucial.
  • Identifying research gaps in pediatric integrative medicine is essential for future development.
  • Further research is needed to fully establish the scope and efficacy of integrative pediatric care.