Related Experiment Video
Updated: Mar 17, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
[Astrocytoma and epilepsy. Clinical case]
Sergio Moreno-Jiménez1, Karen Alejandra Miranda-Fernández2, Mónica García Gutiérrez3
1Centro Neurológico, Centro Médico American British Cowdray, Ciudad de México, México.
Insights
This study presents a rare case of pilocytic astrocytoma in a young adult. Complete surgical resection led to a good prognosis, highlighting the need for follow-up in adult pilocytic astrocytoma patients.
Area of Science:
- Neuro-oncology
- Pediatric Neurosurgery
- Neuropathology
Background:
- Pilocytic astrocytoma is a rare, typically pediatric posterior fossa tumor.
- It can cause hydrocephalus, intracranial hypertension, seizures, or focal neurological deficits.
- Magnetic resonance imaging (MRI) reveals solid and cystic components without significant swelling.
Observation:
- A 22-year-old female presented with a supratentorial pilocytic astrocytoma and epilepsy.
- Histopathology showed a low-grade glial proliferation with specific features like calcifications, piloid areas, Rosenthal fibers, and spongiotic changes.
- The final diagnosis was pilocytic astrocytoma.
Findings:
- This case is unusual due to the patient's age (adult) and the tumor's supratentorial location.
- Surgical intervention resulted in complete tumor resection.
- Long-term prognosis is generally favorable following total resection.
Implications:
- Adult-onset supratentorial pilocytic astrocytoma is rare and presents unique clinical considerations.
- While total resection offers a good prognosis, long-term surveillance is crucial for adult patients due to a higher recurrence risk.
- This case underscores the importance of individualized follow-up protocols for pilocytic astrocytoma in adults.
Background:
Pilocytic astrocytoma is a rare tumour, usually occurring in paediatric ages, and mainly located in the posterior fossa. It can cause hydrocephalus and intracranial hypertension and, less frequently, seizures, or a focal neurological deficit. The main imaging study by magnetic resonance imaging, which shows a tumour with solid and cystic components without peri-lesional swelling. The election treatment is surgical, and the patient is considered cured if a total resection is accomplished.
Clinical Case:
The case is presented of 22-year-old female patient with a supratentorial pilocytic astrocytoma and epilepsy. Histopathology reported a low grade glial proliferation, with an extensive fibrillar matrix, small cells without atypia, extensive calcifications and piloid areas consisting of bipolar fusiform cells, and some Rosenthal fibres. There were also spongiotic areas consisting of multipolar cells and associated microcysts. The final report was a pilocytic astrocytoma.
Conclusions:
Pilocytic astrocytoma is more frequent in paediatric patients and in the posterior fossa. The case presented is of a young female adult with supratentorial location, making it a special case. The surgery achieved a total resection. The long-term prognosis is good, but it is necessary to perform a follow-up, particularly in adult patients because of a higher risk of recurrence.
More Related Videos
09:00Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
Published on: April 15, 2015
09:32Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Antiepileptic Drugs: Glutamate Antagonists
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...