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Related Experiment Video

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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Investigating the Mini-BESTest's construct validity in elderly with Parkinson's disease.

N Löfgren1, M Benka Wallén1, K Sorjonen2

  • 1Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Acta Neurologica Scandinavica
|July 16, 2016
PubMed
Summary
This summary is machine-generated.

The Mini-BESTest effectively assesses dynamic balance in people with Parkinson's disease (PwPD) with mild-to-moderate severity. However, it did not differentiate between recurrent and non-recurrent fallers in this group.

Keywords:
Hoehn and Yahr scalebalance controlfallingpsychometric properties

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Area of Science:

  • Neurology
  • Movement Disorders
  • Rehabilitation Science

Background:

  • The Mini-BESTest is designed to evaluate balance deficits in people with Parkinson's disease (PwPD).
  • Limited research exists on the construct validity of the Mini-BESTest specifically within the PwPD population.
  • This study addresses the need for robust validation of the Mini-BESTest in PwPD.

Purpose of the Study:

  • To validate the Mini-BESTest by comparing its performance in people with Parkinson's disease (PwPD) against healthy controls.
  • To assess if the Mini-BESTest can distinguish between PwPD with varying motor severity (mild vs. moderate).
  • To determine if the Mini-BESTest differentiates between PwPD with a history of recurrent falls versus non-recurrent falls.
  • To examine the convergent and divergent validity of the Mini-BESTest against related and unrelated functional measures.

Main Methods:

  • A cohort of 105 people with Parkinson's disease (PwPD) and 47 healthy controls participated.
  • Participants were categorized by motor severity (mild/moderate) and fall history (recurrent/non-recurrent).
  • Key outcome measures included the Mini-BESTest, Timed Up and Go (TUG), and Unified Parkinson's Disease Rating Scale (UPDRS) Part II.
  • Statistical analyses employed independent t-tests and Spearman's rank correlation coefficient.

Main Results:

  • People with Parkinson's disease (PwPD) scored significantly worse on the Mini-BESTest compared to healthy controls (P<.001).
  • Individuals with moderate motor severity demonstrated poorer Mini-BESTest scores than those with mild severity (P<.001).
  • No significant difference in Mini-BESTest scores was observed between recurrent and non-recurrent fallers (P=.096).
  • Spearman's rho revealed moderate correlation with TUG (ρ=-.470) and poor correlation with UPDRS Part II (ρ=-.211), supporting convergent and divergent validity, respectively.

Conclusions:

  • The Mini-BESTest demonstrates adequate construct validity for measuring dynamic balance in people with Parkinson's disease (PwPD) experiencing mild-to-moderate motor symptoms.
  • The Mini-BESTest's utility in distinguishing fall risk based on fall history (recurrent vs. non-recurrent) requires further investigation.
  • The findings support the Mini-BESTest as a valuable tool for assessing balance in specific PwPD populations.