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Novel biomarkers predicting cardiac function after acute myocardial infarction
Hans-Josef Feistritzer1, Gert Klug1, Sebastian J Reinstadler1
1Department of Cardiology and Angiology, University Clinic of Internal Medicine III, Medical University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria.
British Medical Bulletin
|July 16, 2016
Summary
Biomarkers like cardiac troponins and natriuretic peptides help assess cardiac dysfunction after acute myocardial infarction (AMI). Combining these with novel biomarkers may improve patient risk stratification.
Area of Science:
- Biochemistry
- Cardiology
- Biomarker Discovery
Background:
- Biomarker measurement is cost-effective for assessing cardiac dysfunction and outcomes in acute myocardial infarction (AMI).
- Established biomarkers like cardiac troponins and natriuretic peptides correlate with left ventricular dysfunction and adverse events post-AMI.
Purpose of the Study:
- To review the role of traditional and novel biomarkers in risk stratification for patients with acute myocardial infarction.
- To evaluate the current evidence on established and emerging biomarkers for predicting clinical outcomes in AMI.
Main Methods:
- A systematic search of PubMed was conducted using MeSH terms for 'myocardial infarction' and specific biomarkers.
- Included biomarkers: cardiac troponins, natriuretic peptides, copeptin, galectin-3, corin, fetuin-A, adiponectin, and microRNA.
Main Results:
- Cardiac troponins and natriuretic peptides are established predictors of adverse events in AMI.
- The added value of novel biomarkers for risk stratification remains a subject of debate and requires further investigation.
Conclusions:
- Traditional biomarkers are crucial for managing patients with acute myocardial infarction.
- Integrating novel biomarkers with existing ones holds promise for enhancing the accuracy of risk stratification in AMI patients.
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