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Insights into APC/C: from cellular function to diseases and therapeutics
Zhuan Zhou1, Mingjing He2, Anil A Shah1
1Department of Cell Biology, University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Hillman Cancer Center, HCC2.6c, Pittsburgh, PA 15213 USA.
Cell Division
|July 16, 2016
Summary
The Anaphase-promoting complex/cyclosome (APC/C) is a key regulator of cellular processes. Recent studies highlight its role in disease and potential therapeutic applications.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- The Anaphase-promoting complex/cyclosome (APC/C) is a crucial ubiquitin-protein ligase.
- APC/C regulates vital cellular processes including cell division, differentiation, genome stability, metabolism, cell death, and autophagy.
- Its activity is primarily controlled by Cdc20 and Cdh1 proteins, impacting functions both within and beyond the cell cycle.
Purpose of the Study:
- To review recent insights into the regulatory mechanisms of APC/C.
- To explore the connection between APC/C dysfunction and human diseases.
- To discuss the therapeutic implications of targeting APC/C.
Main Methods:
- Literature review of recent biochemical studies.
- Analysis of 3D structural data.
- Examination of mouse genetic studies.
- Evaluation of small molecule inhibitor research.
Main Results:
- APC/C plays a significant role in numerous cellular functions.
- Dysregulation of APC/C is implicated in various human diseases, including cancer.
- APC/C represents a promising target for therapeutic interventions.
Conclusions:
- APC/C is a central regulator of cellular processes with broad biological significance.
- Understanding APC/C regulation is critical for comprehending disease pathogenesis.
- Targeting APC/C offers potential therapeutic strategies for human diseases.
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