Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased circulating endothelial cells in sickle cell crisis.

S O Sowemimo-Coker1, H J Meiselman, R B Francis

  • 1Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033.

American Journal of Hematology
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Hemorheologic Factors on Middle Cerebral Artery Blood Flow Velocity in Young Individuals.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2016
Same author

Nimodipine and the evolution of hemorheological variables after acute ischemic stroke.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Evaluation of an experimental filter designed for improving the quality of red blood cells (RBCs) during storage by simultaneously removing white blood cells and immunomodulators and improving RBC viscoelasticity and Band 3 proteins.

Transfusion·2013
Same author

The role of hemorheological factors in cardiovascular medicine.

Clinical hemorheology and microcirculation·2013
Same author

Effects of ethanol on red blood cell rheological behavior.

Clinical hemorheology and microcirculation·2012
Same author

Exercise training enhances flow-mediated dilation in spontaneously hypertensive rats.

Physiological research·2011

Sickle cell disease patients show higher circulating endothelial cells, indicating potential endothelial injury during painful crises. This finding is more pronounced in non-smokers experiencing a crisis.

Area of Science:

  • Hematology
  • Vascular Biology
  • Endothelial Cell Biology

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder characterized by abnormal hemoglobin.
  • Endothelial cells form the inner lining of blood vessels and play a crucial role in vascular health.
  • Increased circulating endothelial cells (CECs) are recognized as potential biomarkers of endothelial injury and activation.

Purpose of the Study:

  • To investigate whether individuals with sickle cell anemia exhibit elevated levels of circulating endothelial cells.
  • To assess the correlation between CECs and SCD, particularly during painful crises versus steady states.
  • To evaluate the influence of cigarette smoking on CEC levels in SCD patients and healthy controls.

Main Methods:

  • Quantitative measurement of circulating endothelial cells in peripheral blood samples.

Related Experiment Videos

  • Comparison of CEC counts between 23 SCD patients and 30 healthy control subjects.
  • Stratification of analysis based on disease state (painful crisis vs. steady state) and smoking status.

    • Main Results:

    • Mean CEC levels were significantly higher in SCD patients compared to normal subjects (P < 0.025).
    • CECs were elevated during painful crises (P < 0.01) but not in the steady state among SCD patients.
    • In non-smokers, SCD patients had significantly higher CECs (P < 0.05) than non-smoking controls, especially during crisis (P < 0.01).

    Conclusions:

    • Elevated circulating endothelial cells are significantly associated with sickle cell crisis.
    • Increased CECs in SCD crisis suggest acute endothelial injury during microvascular occlusion events.
    • CECs may serve as a valuable indicator of endothelial damage in sickle cell disease, particularly during acute episodes.