Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

4.5K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Telephone assessment of new hernia referrals-is it possible?

Hernia : the journal of hernias and abdominal wall surgery·2023
Same author

Pancreatoduodenectomy for suspected malignancy: nonmalignant histology confers increased risk of serious morbidity.

Annals of the Royal College of Surgeons of England·2022
Same author

Antiseptic Surgery.

Atlanta medical and surgical journal·2022
Same author

HAADF-STEM image analysis for size-selected platinum nanoclusters.

Journal of microscopy·2020
Same author

Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury.

The British journal of surgery·2019
Same author

Intention to Treat Laparoscopic Versus Open Hemi-Hepatectomy: A Paired Case-Matched Comparison Study.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2019
Same journal

Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Characterization of a novel α-thalassemia deletion (Dongxing deletion; --<sup>DX</sup>) by CNV-seq in a Chinese female with Hb H disease: a case report.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Real-world pegcetacoplan treatment of paroxysmal nocturnal hemoglobinuria patients with an unsatisfactory response to prior therapies.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Distinct clinical, molecular, and treatment response profiles in primary and secondary myelofibrosis: a single-center retrospective study.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Sirolimus-based treatment regimens for antinuclear antibody (ANA)-positive immune thrombocytopenia: a retrospective single-center cohort study.

Hematology (Amsterdam, Netherlands)·2026
Same journal

Relationship between major depressive disorder and venous thromboembolism: a five-ancestry genetic analysis.

Hematology (Amsterdam, Netherlands)·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.3K

Advances in Platelet Counting.

P Harrison1, C Briggs1, S Machin1

  • 1a Department of Haematology , 98, Chenies Mews, University College Hospital , London , WCIE 6HX , UK.

Hematology (Amsterdam, Netherlands)
|July 16, 2016
PubMed
Summary
This summary is machine-generated.

Accurate platelet counts are crucial for managing thrombocytopenia and guiding transfusions. New technologies like 2D optical and immunoplatelet counting, alongside flow cytometry, promise improved reliability, especially for low platelet counts.

Keywords:
Plateletsimmunoplatelet countimpedance platelet countoptical platelet count

More Related Videos

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

885
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.9K

Related Experiment Videos

Last Updated: Mar 17, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.3K
Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

885
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.9K

Area of Science:

  • Hematology
  • Clinical Pathology
  • Medical Technology

Background:

  • Accurate platelet counting is vital for managing platelet disorders, particularly thrombocytopenia, influencing transfusion decisions.
  • Current automated systems and the manual reference method have limitations in accuracy and precision, especially with low or abnormal platelet samples.
  • Existing "1-dimensional" systems struggle to differentiate platelets from debris and exclude large platelets, while manual counts are imprecise and time-consuming.

Purpose of the Study:

  • To review the historical evolution of platelet counting methodologies.
  • To discuss recent advancements in automated platelet counting technologies.
  • To evaluate the advantages and disadvantages of various techniques for improving accuracy, particularly in thrombocytopenic conditions.

Main Methods:

  • Review of historical and recent literature on platelet counting techniques.
  • Analysis of "1-dimensional" cell analysis, "2-dimensional" optical counting, and immunoplatelet counting.
  • Discussion of the new candidate international reference method: flow cytometric immunocounting using the platelet to red blood cell (PLT/RBC) ratio.

Main Results:

  • Traditional methods exhibit significant limitations in accuracy and precision, especially in thrombocytopenia.
  • Emerging technologies like "2-dimensional" optical counting and immunoplatelet counting offer improved discrimination and accuracy.
  • The novel flow cytometric immunocounting method presents a promising candidate for a more reliable international reference standard.

Conclusions:

  • Advancements in platelet counting technology are essential for accurate clinical decision-making in thrombocytopenia.
  • Newer automated methods and reference standards are expected to enhance the overall reliability of platelet counts.
  • Improved accuracy in platelet counting, particularly at low levels, will directly benefit patient care and transfusion strategies.