Herpesvirus Infection in Patients Following Bone Marrow Transplantation: Influence of Viral Reactivation on Prognosis

Viral infections are an important cause of death following bone marrow transplantation. We investigated the clinical significance of herpesvirus infection. The nine subjects consisted of five patients with CML, two with ALL, and one each with AML and the myelodysplastic syndrome. Viral markers were investigated in bronchoalveolar lavage fluid and peripheral blood lymphocytes before and 35 days after bone marrow transplantation, as well as in peripheral blood lymphocytes at 100 days afterwards. Cytomegalovirus DNA became positive in four patients after bone marrow transplantation. Human herpesvirus-6 DNA became positive in two patients and human herpesvirus 7 DNA became negative in the same two patients. Two of the nine patients died of disease recurrence. Two other patients died of complications, and both of them became positive human herpesvirus-6 after the procedure. These results suggested the possibility that infection with not only cytomegalovirus but also other human herpesvirus can influence the prognosis and complications of bone marrow tansplantation.